Case Report: Challenges of insulin and sulfonylurea dosing in an extremely premature infant for the management of KCNJ11-associated neonatal diabetes mellitus

This case report describes the unique and complicated clinical course of a premature neonate with an initially undifferentiated class of NDM requiring a microdose-based approach, i.e., a fraction of a regular dose, to both insulin and SU-based management. This report offers a concise recount of the applied diagnostic and therapeutic procedures while suggesting a decision tree for future NDM management in neonates.

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Publication Details

Journal
Frontiers in Pediatrics
Published
2025-04-16
DOI
https://doi.org/10.3389/fped.2025.1456818
Primary Topic
Pancreatic function and diabetes
Type
article
Field-Weighted Citation Impact
0.00
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article

Case Report: Challenges of insulin and sulfonylurea dosing in an extremely premature infant for the management of KCNJ11-associated neonatal diabetes mellitus

Ishan R Perera, Hirenkumar Patel, Melissa D. Garganta, Brooke Jensen
Frontiers in Pediatrics
Pancreatic function and diabetes
article

Case Report: Challenges of insulin and sulfonylurea dosing in an extremely premature infant for the management of KCNJ11-associated neonatal diabetes mellitus

Ishan R Perera, Hirenkumar Patel, Melissa D. Garganta, Brooke Jensen
article en

Abstract

This case report describes the unique and complicated clinical course of a premature neonate with an initially undifferentiated class of NDM requiring a microdose-based approach, i.e., a fraction of a regular dose, to both insulin and SU-based management. This report offers a concise recount of the applied diagnostic and therapeutic procedures while suggesting a decision tree for future NDM management in neonates.

Frontiers in PediatricsVol. 13
Carilion Roanoke Memorial Hospital (US), Edward Via College of Osteopathic Medicine (US)
Openalex Percentile: Top 86%
Pancreatic function and diabetes
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