Physical activity modifies associations between cerebrospinal fluid tau measures and executive function
Older age was associated with lower levels of physical activity, worse CSF biomarker profiles, and poorer cognition.Physical activity moderates the impact of tau pathology on executive function but shows no significant effect on amyloid-beta pathology.Physical activity may enhance cognitive reserve, thereby attenuating the influence of accumulating AD pathology on cognition.
Authors
- Anja Soldan (ORCID: https://orcid.org/0000-0002-6193-0418)
- Corinne Pettigrew
- Barry Greenberg (ORCID: https://orcid.org/0000-0002-6605-9385)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Adam P. Spira (ORCID: https://orcid.org/0000-0003-1507-0995)
- Ryan James Dougherty (ORCID: https://orcid.org/0000-0002-8640-9549)
- Marilyn Albert
Institutions
- Rutgers, The State University of New Jersey (US)
- Johns Hopkins University (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70085
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- National Institutes of Health