The CentiMarker project: Standardizing quantitative Alzheimer's disease fluid biomarkers for biologic interpretation
Comparing fluid biomarkers without appreciating their magnitude relative to the disease can be challenging. We propose a CentiMarker metric to standardize biomarker measures from normal (0) and nearly maximum abnormal AD (100) ranges. CentiMarkers make the treatment effect more comparable across various biomarkers than when using the original scales.
Authors
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Carlos C Cruchaga (ORCID: https://orcid.org/0000-0002-0276-2899)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Oskar Hansson (ORCID: https://orcid.org/0000-0001-8467-7286)
- Eric McDade (ORCID: https://orcid.org/0000-0002-6764-3866)
- Charlotte Elisabeth Teunissen (ORCID: https://orcid.org/0000-0002-4061-0837)
- Laura Ibáñez (ORCID: https://orcid.org/0000-0003-2381-7059)
- Suzanne E. Schindler (ORCID: https://orcid.org/0000-0002-1680-1465)
- Yan Li
- Leslie M. Shaw (ORCID: https://orcid.org/0000-0002-7650-1210)
- Yuchen Cao (ORCID: https://orcid.org/0000-0002-7495-3694)
- Jigyasha Timsina (ORCID: https://orcid.org/0000-0003-4794-9187)
- Guoqiao Wang (ORCID: https://orcid.org/0000-0002-6808-8737)
- Chengjie Xiong
- Henrik Zetterberg
- Kaj Blennow
Institutions
- Mayo Clinic (US)
- Lund University (SE)
- Washington University in St. Louis (US)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Amsterdam Neuroscience (NL)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Skåne University Hospital (SE)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Institut du Cerveau (FR)
- Indiana University School of Medicine
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/alz.14587
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- U.S. Department of Defense
- Foundation for the National Institutes of Health
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Biogen
- F. Hoffmann-La Roche
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Japan Agency for Medical Research and Development
- GHR Foundation
- Korea Health Industry Development Institute
- Eisai
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- Ministry of Science and ICT, South Korea
- Fleni
- National Institutes of Health
- Genentech
- Avid Radiopharmaceuticals
- Canadian Institutes of Health Research
- Instituto de Salud Carlos III
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering