ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer
This study revealed that ADAR1-high TAMs are crucial in regulating drug resistance in CRC and that targeting ADAR1 in TAMs could be a promising treatment approach for overcoming drug resistance in CRC.
Authors
- Yuzo Umeda (ORCID: https://orcid.org/0000-0002-5778-6863)
- Hiroshi Tazawa (ORCID: https://orcid.org/0000-0003-4658-1050)
- Toshiaki Takahashi (ORCID: https://orcid.org/0000-0002-8188-2505)
- Ajay Kumar Goel (ORCID: https://orcid.org/0000-0001-7930-6974)
- Yuki Matsumi (ORCID: https://orcid.org/0000-0003-3874-7372)
- Masashi Kayano
- Hideki Yamamoto (ORCID: https://orcid.org/0000-0001-7113-0070)
- Hiroyuki Kishimoto (ORCID: https://orcid.org/0000-0001-8174-3508)
- Kazuya Moriwake (ORCID: https://orcid.org/0009-0009-3367-1058)
- Sho Takeda (ORCID: https://orcid.org/0000-0001-7908-9797)
- Hiroyuki Michiue (ORCID: https://orcid.org/0000-0002-9215-4888)
- Kunitoshi Shigeyasu (ORCID: https://orcid.org/0000-0002-1266-2875)
- Shunsuke Kagawa
- Toshiyoshi Fujiwara (ORCID: https://orcid.org/0000-0002-5377-6051)
- Yoshitaka Kondo (ORCID: https://orcid.org/0000-0002-0046-9429)
- Fuminori Teraishi (ORCID: https://orcid.org/0000-0001-5133-2644)
- Kazuhiro Yoshida (ORCID: https://orcid.org/0000-0003-1408-0104)
- Kosei Takagi (ORCID: https://orcid.org/0000-0003-2267-2441)
- Keiichiro Nakamura (ORCID: https://orcid.org/0000-0002-4609-5258)
- Shuya Yano
- Yoshiko Mori (ORCID: https://orcid.org/0000-0003-4948-8142)
- Kazuya Yasui
- Hibiki Umeda
- Tomokazu Fuji (ORCID: https://orcid.org/0000-0002-7107-6518)
Institutions
- Okayama University (JP)
- Kawasaki Medical School (JP)
- City of Hope (US)
- Social Insurance Saitama Chuo Hospital (JP)
- Ehime University (JP)
- Beckman Research Institute
- Saitama Medical University (JP)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12943-025-02312-y
- Citations
- 14
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 11.28
Funders
- Takeda Science Foundation
- Lotte Foundation
- Japan Society for the Promotion of Science