ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer

This study revealed that ADAR1-high TAMs are crucial in regulating drug resistance in CRC and that targeting ADAR1 in TAMs could be a promising treatment approach for overcoming drug resistance in CRC.

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Publication Details

Journal
Molecular Cancer
Published
2025-04-16
DOI
https://doi.org/10.1186/s12943-025-02312-y
Citations
14
Primary Topic
RNA regulation and disease
Type
article
Field-Weighted Citation Impact
11.28

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article

ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer

Yuzo Umeda, Hiroshi Tazawa, Toshiaki Takahashi, Ajay Kumar Goel et al.
14 citations
Molecular Cancer
RNA regulation and disease
11.28
article

ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer

Yuzo Umeda, Hiroshi Tazawa, Toshiaki Takahashi, Ajay Kumar Goel, Yuki Matsumi, Masashi Kayano, Hideki Yamamoto, Hiroyuki Kishimoto, Kazuya Moriwake, Sho Takeda, Hiroyuki Michiue, Kunitoshi Shigeyasu, Shunsuke Kagawa, Toshiyoshi Fujiwara, Yoshitaka Kondo, Fuminori Teraishi, Kazuhiro Yoshida, Kosei Takagi, Keiichiro Nakamura, Shuya Yano, Yoshiko Mori, Kazuya Yasui, Hibiki Umeda, Tomokazu Fuji
article en
14 citations

Abstract

This study revealed that ADAR1-high TAMs are crucial in regulating drug resistance in CRC and that targeting ADAR1 in TAMs could be a promising treatment approach for overcoming drug resistance in CRC.

Molecular CancerVol. 24(1)
Okayama University (JP), Kawasaki Medical School (JP), City of Hope (US), Social Insurance Saitama Chuo Hospital (JP), Ehime University (JP), Beckman Research Institute, Saitama Medical University (JP)
Takeda Science Foundation, Lotte Foundation, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 1%
RNA regulation and disease
11.28
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