Anaphylactic Reaction due to Ferric Carboxymaltose: A Case Report

This case report describes a 24-year-old female patient admitted with severe iron deficiency anemia, presenting with generalized weakness, easy fatigability, and decreased appetite. The patient was initially treated with oral iron supplements, intravenous iron sucrose, and blood transfusion. However, the patient developed adverse reactions to both blood transfusions and iron sucrose. Subsequently, ferric carboxymaltose (FCM) was administered, but the patient experienced symptoms suggestive of an anaphylactic reaction, including hypotension, respiratory distress, and decreased oxygen saturation. The FCM dose was reduced and eventually discontinued. The causality assessment for both iron sucrose and FCM was determined to be 'Possible' using the WHO UMC scale and Naranjo scale. This case highlights the rare but potentially life-threatening anaphylactic reactions associated with intravenous iron preparations, emphasizing the need for healthcare providers to remain vigilant during administration and to be prepared to manage such reactions promptly. This study underscores the importance of pharmaceutical care and adherence to administration guidelines to minimize the risks of intravenous iron therapies.