Role of biomechanical factors in plaque rupture and erosion: insight from intravascular imaging based computational modeling
Coronary biomechanics including structural wall stress and strain on the vessel wall and flow wall shear stress on the endothelial surface play a vital role in plaque progression, rupture and erosion. This review summarizes recent advances in coronary intravascular imaging, image-based biomechanical modeling, and their applications in investigating possible biomechanical mechanisms of plaque rupture and erosion, and developing interventional therapies targeting unfavorable mechanical conditions for personalized treatment and precision medicine.
Authors
- Gary S. Mintz (ORCID: https://orcid.org/0000-0003-3296-8705)
- Zhao Chen (ORCID: https://orcid.org/0000-0002-3880-3664)
- Rui Lv (ORCID: https://orcid.org/0000-0002-9503-1568)
- Dalin Tang (ORCID: https://orcid.org/0000-0002-6965-6417)
- Bo Yu (ORCID: https://orcid.org/0000-0002-2045-8567)
- Akiko Maehara (ORCID: https://orcid.org/0000-0002-1910-8447)
- Mingming Yang (ORCID: https://orcid.org/0000-0003-4484-0979)
- Haibo Jia (ORCID: https://orcid.org/0009-0004-7738-3238)
- Liang Wang (ORCID: https://orcid.org/0000-0002-5247-6727)
- Xiaoya Guo (ORCID: https://orcid.org/0009-0001-9289-3832)
- Yanwen Zhu
Institutions
- Worcester Polytechnic Institute (US)
- Harbin Medical University (CN)
- Nanjing University of Posts and Telecommunications (CN)
- Southeast University (BD)
- Second Hospital of Shandong University (CN)
- Zhongda Hospital Southeast University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Cardiovascular Research Foundation (US)
- Southeast University (CN)
- Columbia University (US)
Publication Details
- Journal
- npj Cardiovascular Health
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1038/s44325-025-00048-8
- Citations
- 4
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Natural Science Foundation of Shandong Province