The single-cell atlas of short-chain fatty acid receptors in human and mice hearts
We present the atlas of <i>FFAR2/3</i> in the whole human body, normal and infarcted hearts at single-cell resolution. We also illustrated the entire atlas of <i>FFAR2/3</i> in normal/ischemic hearts of newborn and adult mice by combining public and newly built sc/snRNA-seq datasets. These findings provide valuable information on the possible effect of SCFAs via FFAR2/3 in the heart and valuable references for future studies.
Authors
- Qiang Zhao (ORCID: https://orcid.org/0000-0002-8930-3854)
- Xiaojun He (ORCID: https://orcid.org/0000-0002-7966-3637)
- Zhizhao Song
- Xinming Wang (ORCID: https://orcid.org/0000-0001-5290-8254)
- Qiang Long (ORCID: https://orcid.org/0009-0000-9664-0712)
- Yecen Zhang
- Shixing Huang (ORCID: https://orcid.org/0000-0002-6348-7253)
- Wei Gao (ORCID: https://orcid.org/0000-0003-3541-9568)
- Xuemei Chen (ORCID: https://orcid.org/0000-0002-5209-1157)
- Feifei Li (ORCID: https://orcid.org/0000-0003-4733-6268)
- Zhaoxi Qi
- Qiang Wang (ORCID: https://orcid.org/0000-0002-3079-6383)
- Xiaomei Yang (ORCID: https://orcid.org/0000-0002-4081-4207)
- Yiming Zhong (ORCID: https://orcid.org/0000-0002-9635-4238)
- Bei Qian (ORCID: https://orcid.org/0000-0003-1524-7340)
- Xu Li (ORCID: https://orcid.org/0000-0002-0765-5494)
- Lan Chang
Institutions
- Tongji University (CN)
- Johns Hopkins University (US)
- Shandong University (CN)
- Johns Hopkins Medicine (US)
- Ruijin Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Shanghai Tenth People's Hospital (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1538384
- Citations
- 1
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.81