Regulatory element map of sheep reproductive tissues: functional annotation of tissue-specific strong active enhancers
Enhancers were identified as critical drivers of tissue-specific functions, operating through sequence-specific transcription factor binding and direct regulation of target genes. Key transcription factors associated with reproductive function included <i>INHBA</i> (ovary), <i>KITLG</i> (oviduct), <i>Snai2</i> (cervix), <i>WNT7A</i> (uterine horn), <i>FOLR1</i> (uterine body), and <i>SALL1</i> (shared uterine regions). Additionally, our findings support the potential of sheep as a promising model for investigating embryonic development and miscarriage. This work lays a theoretical foundation for future research into the molecular mechanisms of complex traits and diseases in sheep.
Authors
- Hao Yang (ORCID: https://orcid.org/0000-0003-4172-012X)
- Zhangyuan Pan (ORCID: https://orcid.org/0000-0001-5394-3203)
- Zijun Zhang (ORCID: https://orcid.org/0000-0002-9869-7381)
- Mingxing Chu (ORCID: https://orcid.org/0000-0002-5164-0310)
- Chunhuan Ren (ORCID: https://orcid.org/0000-0002-1704-059X)
- Qiangjun Wang (ORCID: https://orcid.org/0000-0003-2060-1527)
- Jiahong Chen (ORCID: https://orcid.org/0000-0003-4195-5578)
- Shiwen Zhang (ORCID: https://orcid.org/0000-0002-9341-3765)
- Zhu Meng (ORCID: https://orcid.org/0009-0004-0647-3615)
Institutions
- Anhui Agricultural University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Sanya University (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fvets.2025.1564148
- Citations
- 3
- Primary Topic
- Animal Genetics and Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China