Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5 × FAD mice
The present study demonstrated that METTL16 enhances learning and memory in 5 × FAD mice by regulating MAT2A mRNA m<sup>6</sup>A methylation, which leads to increased expression levels of PSD95 and Syp, greater dendritic spine density, and reduced Aβ<sub>1-42</sub> accumulation in the hippocampus. These findings reveal a novel approach for investigating the pathophysiological role of METTL16 in AD and offer new insights for developing of potential therapeutic targets for AD.
Authors
- Xiaowei Ma (ORCID: https://orcid.org/0000-0003-0352-5809)
- Sufang Jiang
- Fangzhen Guo
- Yan Zhao (ORCID: https://orcid.org/0000-0003-4632-5647)
- Huiling Ren
- Chang Wang (ORCID: https://orcid.org/0009-0005-1630-9453)
- Sha Li (ORCID: https://orcid.org/0000-0002-4869-3809)
- Wei Liu (ORCID: https://orcid.org/0009-0007-4263-7383)
- Huan Chen (ORCID: https://orcid.org/0000-0003-3061-134X)
- Bingyu Chen (ORCID: https://orcid.org/0009-0007-0322-9520)
- Lining Huang (ORCID: https://orcid.org/0000-0001-5754-2706)
- Huixian Cui (ORCID: https://orcid.org/0000-0001-7395-2094)
Institutions
- Hebei Medical University (CN)
- Ministry of Education of the People's Republic of China (CN)
- Third Hospital of Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fnagi.2025.1572976
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China