The antidepressant effects of kaji-ichigoside F1 via activating PPAR-γ/CX3CR1/Nrf2 signaling and suppressing NF-κB/NLRP3 signaling pathways
In conclusion, these results suggest that KF1 is an effective alleviator of LPS-induced depression-like effects <i>in vivo</i> and <i>in vitro</i>. These effects were associated with activating PPARγ/CX3CR1/Nrf2 signaling, and suppressing NF-κB/NLRP3 signaling pathways.
Authors
- Lang Zhou (ORCID: https://orcid.org/0000-0003-1443-4531)
- Lilang Li (ORCID: https://orcid.org/0009-0004-2387-076X)
- Liangqun Li (ORCID: https://orcid.org/0000-0002-8063-9175)
- Xiaosheng Yang (ORCID: https://orcid.org/0000-0003-1535-3282)
- Lishou Yang
- Faju Chen
- Yu Wang (ORCID: https://orcid.org/0000-0002-8043-9165)
- Ming Gao (ORCID: https://orcid.org/0000-0003-4551-0621)
- Li Wang (ORCID: https://orcid.org/0000-0001-8527-6345)
- Qing Zhang (ORCID: https://orcid.org/0000-0002-1160-2715)
- Juan Yang (ORCID: https://orcid.org/0000-0003-4077-920X)
- Maoyang Huang
- Qi‐Ji Li (ORCID: https://orcid.org/0000-0003-0710-4569)
- Guanping Yao
Institutions
- Guiyang Medical University (CN)
- Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fphar.2025.1569888
- Citations
- 3
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.67
Funders
- National Natural Science Foundation of China