Utilizing bioinformatics to identify biomarkers and analyze their expression in relation to immune cell ratios in femoral head necrosis
Our study identified CASP8, TNFRSF1A, AKT1, XIAP, STAT3 and BCL2L1 as potential biomarkers for NFH patients and elucidated the immune cell types with the strongest association to these markers. These insights may be crucial for the early diagnosis, understanding of the pathophysiological mechanisms, and the development of treatment strategies for NFH.
Authors
- Yu‐Xiong Su (ORCID: https://orcid.org/0000-0001-7143-3370)
- Li Zhao (ORCID: https://orcid.org/0000-0001-7374-3348)
- Yao Lu (ORCID: https://orcid.org/0000-0002-6715-4640)
- Li Zhong (ORCID: https://orcid.org/0000-0003-3815-6484)
- Zhilong Huang (ORCID: https://orcid.org/0000-0001-8796-4969)
- Qian Wang
- Yao Li (ORCID: https://orcid.org/0000-0003-4330-6440)
- Teng Ma (ORCID: https://orcid.org/0000-0002-5849-2138)
- Ming Li (ORCID: https://orcid.org/0000-0002-2679-6137)
- Dongchen Li (ORCID: https://orcid.org/0009-0002-6320-9736)
- L. Sun (ORCID: https://orcid.org/0000-0003-2667-2932)
Institutions
- Xi'an Honghui Hospital (CN)
- Yan'an University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fphys.2025.1373721
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00