Synthesis of a novel mitochondrial fluorescent probe - killing cancer cells in vitro and in vivo
In summary, MPM-1 demonstrates the ability to inhibit the growth of CRC and LUNG by targeting mitochondria and modulating several signaling pathways that attenuate tumor cell migration and proliferation while promoting apoptosis. This research underscores the potential of MPM-1 as a tumor suppressor and lays a robust foundation for the future development of innovative anticancer therapies that target mitochondrial functions.
Authors
- Chengjin Liang (ORCID: https://orcid.org/0000-0002-3008-1134)
- Yan-yan Zhan (ORCID: https://orcid.org/0000-0003-3962-0349)
- Yipeng Liu (ORCID: https://orcid.org/0000-0001-8658-5764)
- Xinzhuang Shen
- Wenzhi Shen (ORCID: https://orcid.org/0000-0002-4251-6035)
- Yuan Ma (ORCID: https://orcid.org/0000-0002-7846-4863)
- Xiaoyuan Zhang (ORCID: https://orcid.org/0000-0002-8156-6414)
- Yifei Li
- Zongjun Liu (ORCID: https://orcid.org/0000-0003-1845-525X)
- Xiaowen Yang (ORCID: https://orcid.org/0000-0002-0673-9020)
- Yehao Yan
Institutions
- Jining Medical University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fphar.2025.1543559
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00