Influence of gut microbiota and immune markers in different stages of colorectal adenomas
This study highlights the dynamic alterations in gut microbiota composition and their potential influence on the regulation of inflammatory cytokines and PD-L1 expression during CRA progression. The enrichment of protective taxa, such as <i>Anaerostipes</i> and <i>Blautia</i>, in the normal group emphasizes their potential role in mitigating adenoma progression. Dietary modulation to promote the proliferation of these beneficial bacteria could serve as a promising strategy to improve colorectal health. Future research should further explore the specific relationships between dietary components, gut microbiota, and metabolic pathways, and assess the effects of dietary interventions on gut health.
Authors
- Mingke Li (ORCID: https://orcid.org/0000-0001-6310-4964)
- Xianmei Wang (ORCID: https://orcid.org/0000-0002-6273-3096)
- Yu Li (ORCID: https://orcid.org/0009-0002-9085-8803)
- Lihong Lu (ORCID: https://orcid.org/0000-0002-9665-3246)
- Dan Zhang (ORCID: https://orcid.org/0000-0002-6133-8318)
- Meng Yang (ORCID: https://orcid.org/0000-0001-5630-6357)
- Jiangkun Yu (ORCID: https://orcid.org/0000-0002-1832-7832)
- Hang Chen (ORCID: https://orcid.org/0000-0003-1410-4284)
- Qingqing Zhou (ORCID: https://orcid.org/0000-0001-9224-0914)
- Lanqing Ma (ORCID: https://orcid.org/0000-0002-9738-9934)
- Hui Wang (ORCID: https://orcid.org/0000-0002-4821-4839)
- Minshan Huang
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fmicb.2025.1556056
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.84