Multi - dimensional mechanism analysis of Choerospondias axillaris (Roxb.) Burtt et Hill in treating kidney stones: network pharmacology, molecular docking and in vitro experimental verification
CA can attenuate the damage and adhesion of COM crystals to cells through multiple mechanisms. These include enhancing the cellular antioxidant capacity, regulating the activation of the NLRP3 inflammasome, reducing the expression of the crystal adhesion protein OPN, and preventing the further aggregation or mineralization of CaOx crystals. Thus, CA achieves the objective of treating kidney stones.
Authors
- Ke Yang (ORCID: https://orcid.org/0000-0002-1870-1134)
- Mengsheng Qiu (ORCID: https://orcid.org/0000-0001-6038-3718)
- Qin Sun (ORCID: https://orcid.org/0000-0002-3216-5307)
- Chunhui Zeng (ORCID: https://orcid.org/0000-0003-0910-5178)
- Xin Yin (ORCID: https://orcid.org/0000-0002-9892-7845)
- Yuxin Zhang (ORCID: https://orcid.org/0000-0003-4698-5645)
- Yujun Li (ORCID: https://orcid.org/0000-0002-2948-995X)
- Jiaoxia Yan (ORCID: https://orcid.org/0009-0009-8186-3361)
- S. Li (ORCID: https://orcid.org/0000-0001-9781-2336)
Institutions
- Guangxi University (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fphar.2025.1501386
- Citations
- 1
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China