Network pharmacology-based prediction and molecular docking-based strategy to investigate the potential mechanism of Leonurus japonicus Houtt. Against myocardial ischemia reperfusion injury
The mechanism of LJH in the treatment of MIRI was mainly related to the activation of TNF signaling pathway and NF-kappa B signaling pathway, and the regulation of TNF, VCAM1, and MMP9 protein expression.
Authors
- Zilian Zhan
- Qiang Xu (ORCID: https://orcid.org/0000-0002-8433-8687)
- Yadong Wang (ORCID: https://orcid.org/0000-0002-8815-6397)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-6500-6556)
- Xuan Liu (ORCID: https://orcid.org/0000-0001-5629-9986)
Institutions
- Hebei University of Technology (CN)
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Cardiothoracic Surgery
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s13019-025-03425-7
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00