Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of organic cation transporter 1 and P-glycoprotein
HH possibly reduced pitolisant's brain concentration and efficacy by altering the expression of OCT1 and P-gp transporters. A 40 mg/kg dose was necessary for an effective anti-fatigue response. Pitolisant shows potential for supporting circadian rhythm regulation in shift workers and individuals suffering from jet lag. When used under HH conditions, adjusting the dose and frequency may be necessary due to altered pharmacokinetics.
Authors
- Wei‐Tien Chang (ORCID: https://orcid.org/0000-0002-1880-7932)
- Fengzhou Liu
- Gang Zhao (ORCID: https://orcid.org/0000-0002-0201-1825)
- Yajuan Li (ORCID: https://orcid.org/0000-0003-2328-6956)
- Mengyuan Liu (ORCID: https://orcid.org/0000-0001-5085-8716)
- Junhui Xue
- Hui Shen
Institutions
- Northwest University (CN)
- People 's Liberation Army 451 Hospital (CN)
- Air Force Engineering University (CN)
- Xi'an Medical University (CN)
- Air Force Institute of Aviation Medicine Affiliated Hospital (CN)
- Xijing Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fphar.2025.1564174
- Citations
- 1
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 1.16