Neutrophil-to-lymphocyte ratio predicts a poor prognosis for penile cancer with an immunosuppressive tumor microenvironment
The NLR is an effective, simple and independent prognostic indicator for PC. A high NLR is associated with an immunosuppressive TME and poor outcomes.
Authors
- Xinpei Deng (ORCID: https://orcid.org/0000-0001-9973-2559)
- Xingliang Tan (ORCID: https://orcid.org/0000-0002-4015-4982)
- Yi Tang (ORCID: https://orcid.org/0000-0003-1163-9152)
- Qianghua Zhou (ORCID: https://orcid.org/0000-0001-7483-0478)
- Chichen Zhang (ORCID: https://orcid.org/0000-0003-1095-9939)
- Weicheng Wu (ORCID: https://orcid.org/0000-0001-5605-3898)
- Wensu Wei (ORCID: https://orcid.org/0000-0002-8172-3221)
- Zhicheng Liu (ORCID: https://orcid.org/0000-0002-5950-409X)
- Kai Yao (ORCID: https://orcid.org/0000-0002-8122-430X)
- Yanjun Wang (ORCID: https://orcid.org/0000-0002-8178-9925)
- Shaohua Chen (ORCID: https://orcid.org/0000-0003-4945-5914)
- Jīng Li (ORCID: https://orcid.org/0000-0001-9714-5924)
- Hang Li (ORCID: https://orcid.org/0000-0003-3058-8733)
- Rongyuan Zheng (ORCID: https://orcid.org/0000-0002-0090-956X)
- Shengjie Guo (ORCID: https://orcid.org/0000-0001-7953-8775)
- Yiqi Yu (ORCID: https://orcid.org/0000-0002-0789-0742)
- Qingling Xie
- Juexiao Chen
- Zhiming Wu (ORCID: https://orcid.org/0000-0001-8988-6060)
Institutions
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1568825
- Citations
- 9
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 18.06
Funders
- Gilead Sciences
- Beijing Xisike Clinical Oncology Research Foundation
- China Postdoctoral Science Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province