The potential crosstalk genes and molecular mechanisms between systemic lupus erythematosus and periodontitis
This study identifies 8 hub genes that could potentially serve as diagnostic markers for both SLE and PD, highlighting the importance of VCAN and LY96 in diagnosis. Moreover, the involvement of the PI3K-Akt signaling pathway in both diseases suggests its significant role. These identified key genes and signaling pathways lay the groundwork for deeper comprehension of the interplay between SLE and PD.
Authors
- Jinge Huang (ORCID: https://orcid.org/0000-0002-7466-5991)
- Qingmiao Zhu (ORCID: https://orcid.org/0009-0008-7675-2619)
- Xiaolong Li (ORCID: https://orcid.org/0000-0002-6111-9000)
- Kai Zhao (ORCID: https://orcid.org/0000-0002-9662-375X)
- Mengyu Zhu
- Ting Zhao (ORCID: https://orcid.org/0000-0002-9921-3692)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fgene.2025.1527713
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67