Investigating the genetic association of mitochondrial DNA copy number with neurodegenerative diseases
Although mitochondrial dysfunction is implicated in the pathogenesis of NDs, no clear evidence supports a causal role for mtDNA copy number. The relationship between mtDNA copy number and NDs is likely mediated by more complex molecular regulatory mechanisms. Further research is required to elucidate these intricate interactions.
Authors
- Xinling Yang (ORCID: https://orcid.org/0000-0002-4517-0500)
- Xiaobei Wang (ORCID: https://orcid.org/0000-0001-5499-5582)
- Huan Xia (ORCID: https://orcid.org/0000-0002-2181-1713)
- Zihao Wang (ORCID: https://orcid.org/0000-0002-9685-2034)
- Song Jiang (ORCID: https://orcid.org/0009-0000-0904-7401)
- Xinyu Du (ORCID: https://orcid.org/0009-0001-7773-1835)
- Meirong Gao
Institutions
- Xinjiang Medical University (CN)
- Second Affiliated Hospital of Jilin University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12883-025-04176-7
- Citations
- 7
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Xinjiang
- National Human Genome Research Institute