Modulation of the gut-bone axis: Lacticaseibacillus paracasei LC86 improves bone health via anti-inflammatory metabolic pathways in zebrafish models of osteoporosis and cartilage damage
LC86 significantly improved bone health, cartilage structure, and gut microbiota composition in a Dexamethasone-induced zebrafish model, supporting its potential as a therapeutic strategy for osteoporosis and cartilage injury via modulation of the gut-bone axis.
Authors
- Zhonghui Gai
- Yihui Cai (ORCID: https://orcid.org/0000-0003-3341-6750)
- Yao Dong (ORCID: https://orcid.org/0000-0002-4425-3793)
- Kang Zou (ORCID: https://orcid.org/0000-0002-4959-1951)
- Zhipeng Zhou (ORCID: https://orcid.org/0000-0003-0775-8220)
- Yukun Sun (ORCID: https://orcid.org/0000-0002-0604-9732)
- Mei Han (ORCID: https://orcid.org/0009-0004-7185-158X)
Institutions
- Nanjing Agricultural University (CN)
- Hubei University of Medicine (CN)
- University of Leeds (GB)
- Shanghai Business School (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1493560
- Citations
- 3
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Fundamental Research Funds for the Central Universities