<scp>LncRNA ENSSSCG00000035331</scp> Alleviates Hippocampal Neuronal Ferroptosis and Brain Injury Following Porcine Cardiopulmonary Resuscitation by Regulating the <scp>miR</scp> ‐let7a/ <scp>GPX4</scp> Axis
Our findings highlighted that ENSSSCG00000035331 was a critical regulator of hippocampal neuronal ferroptosis after CA and resuscitation by targeting the miR-let7a/GPX4 axis, and additionally, sulforaphane might be a promising therapeutic agent for alleviating post-resuscitation brain injury by regulating the signaling axis mentioned above.
Authors
- Jiefeng Xu
- Xingui Wu (ORCID: https://orcid.org/0000-0002-8973-3790)
- Xianlong Wu
- Lu He (ORCID: https://orcid.org/0000-0001-8401-0588)
- Lulu Li (ORCID: https://orcid.org/0000-0002-7790-090X)
- Ziwei Chen (ORCID: https://orcid.org/0009-0001-8242-3853)
- Wenbin Zhang (ORCID: https://orcid.org/0000-0002-7681-7530)
- Pin Lan (ORCID: https://orcid.org/0009-0000-0374-218X)
- Qijiang Chen
- Mao Zhang
Institutions
- Wenzhou Medical University (CN)
- Lishui Central Hospital (CN)
- Taizhou First People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Ningbo First Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70377
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China