Association of 24‐h Energy Intake Behavior With Depressive Symptoms: Findings From the National Health and Nutrition Examination Survey

<b>Objective:</b> Appetite changes are a significant clinical feature of depression, with circadian rhythms disruption being a crucial mechanism in depression. However, the specific role of eating rhythms in depression remains unclear. This study aimed to assess the relationship between energy intake rhythmicity and depressive symptoms. <b>Methods:</b> A total of 34,974 noninstitutionalized individuals were recruited from the National Health and Nutrition Examination Survey. To investigate the relationship between 24-h energy intake and depressive symptoms, covariate-adjusted sample-weighted regressions were employed. The study analyzed various aspects of energy intake rhythmicity, including the proportion of energy intake from non-meals and meal times, as well as the proportion of energy intake across meals and various time periods (morning, midday, afternoon, evening, night, and overnight). <b>Results:</b> A high proportion of energy intake from non-meals (adjusted odds ratio [OR] = 1.11, 95% confidence interval [CI]: 1.08-1.15) was associated with higher depressive symptoms. The proportion of breakfast energy intake in total daily energy intake was nonlinearly associated with depressive symptoms. In participants with a breakfast energy intake below 20%, the prevalence of depressive symptoms decreased by 15% (adjusted OR = 0.85, 95% CI: 0.75-0.96) per each 10% increment in the proportion of breakfast energy intake. A U-shaped relationship was identified between the timing of the day's last energy intake and depressive symptoms, with the lowest prevalence occurring at 7:48 PM (before 7:48 PM: adjusted [OR = 0.96, 95% CI: 0.94-0.98]; after 7:48 PM: adjusted [OR = 1.11, 95% CI: 1.03-1.20]). <b>Conclusions:</b> Among adults in the United States, the proportion of energy consumed from non-meals was associated with higher depressive symptoms. Adequate energy intake at breakfast and moderate end-times of energy intake were linked to reduced depressive symptoms. These results may contribute to designing of future studies on dietary rhythm interventions for managing depression.