Comparison of Letrozole vs. Clomiphene Citrate for Ovulation Induction in Infertility Patients with Polycystic Ovarian Syndrome

Background: In women of reproductive age, polycystic ovary syndrome or PCOS has become themost frequent cause of anovulatory infertility. Although CC has been used in the past as the firstline treatment for ovulation induction, recent challenges such as antiestrogen city of the drug andpoor response in certain patients have seen use of the like of letrozole an aromatase inhibitor.Aim: This five-year multicentre study aimed at comparing the effectiveness, safety, and ovulation –related pregnancy rates between two methods of ovulation induction – letrozole and clomiphenecitrate – in women with PCOS.