Mechanisms of a Patented Chinese Herbal Medicine for Treating Hypothyroidism in In Vitro Fertilization-Embryo Transfer: A Combination of Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation
Quercetin, beta-sitosterol, kaempferol, 7-ketocholesterol, and rehmapicrogenin were determined to be the active ingredients in QUF6. The potential mechanism of action for QUF6 may involve modulation of TNF, IL6, IL1B, BCL2, PTSG2, TP53, and EGF to regulate oxidative stress levels, inflammation responses, and apoptosis processes associated with hypothyroidism during IVF-ET.
Authors
- Weihuan Hu (ORCID: https://orcid.org/0000-0002-3548-2797)
- Fan Qu (ORCID: https://orcid.org/0000-0003-1851-1514)
- Chang Liu (ORCID: https://orcid.org/0000-0003-0508-4357)
- Fangfang Wang (ORCID: https://orcid.org/0000-0002-1006-867X)
- Xiaoling Feng (ORCID: https://orcid.org/0000-0002-8724-8855)
- Tianyi Zhou (ORCID: https://orcid.org/0000-0003-1074-0056)
- Jue Zhou (ORCID: https://orcid.org/0000-0002-9656-9503)
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- Women's Hospital, School of Medicine, Zhejiang University (CN)
- Zhejiang Gongshang University (CN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-04-16
- DOI
- https://doi.org/10.2174/0113816128364578250212094405
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00