Assessment of longitudinal systolic function using tissue motion annular displacement in cats with hypertrophic cardiomyopathy: a prospective case-control study

ObjectivesThe aim of this study was to investigate left ventricular (LV) longitudinal systolic function in cats with hypertrophic cardiomyopathy (HCM) and healthy control cats using tissue motion annular displacement (TMAD).MethodsThe study included 26 control cats and 21 HCM cats. All cats underwent assessment using two-dimensional echocardiography, M-mode echocardiography, pulsed-wave Doppler, tissue Doppler imaging techniques, longitudinal strain and TMAD.ResultsGlobal TMAD and percentage (%) global TMAD were not influenced by breed, sex, age or heart rate. Mean global TMAD and % global TMAD significantly decreased in the HCM group (2.86 ± 0.86 mm and 11.46% ± 3.37%, respectively) compared with the control group (3.95 ± 0.89 mm and 16.12% ± 2.94%, respectively) (<i>P</i> <0.001 for both), suggesting LV longitudinal systolic dysfunction in HCM cats. LV fractional shortening showed no difference between the control (52.76% ± 11.63%) and the HCM groups (59.80% ± 13.51%) (<i>P</i> = 0.061). Global TMAD and % global TMAD were significantly correlated with global longitudinal strain (<i>P</i> <0.001). The intraclass correlation coefficient of global TMAD and % global TMAD was considered moderate.Conclusions and relevanceGlobal TMAD and % global TMAD were significantly decreased in cats with HCM compared with the control group, and were sensitive and repeatable techniques for evaluating LV longitudinal systolic dysfunction in cats with HCM.