Epigenetics‐Driven Appetite System Disorders and <scp>PI3K</scp>/<scp>AKT</scp> Signaling Activation Mediate a Weight Gain Resistance Phenotype Induced by a High‐Fat Diet in Male Rats
Our study suggests that 5mC-mediated molecular disturbances in the hypothalamic appetite system and activation of PI3K/Akt signaling in the VMH may serve as a potential pathogenic basis for HFWR.
Authors
- Min Guo (ORCID: https://orcid.org/0000-0003-1722-2163)
- Lu‐Yi Ye
- Ming‐Jie Li
- Huajun Zheng (ORCID: https://orcid.org/0000-0002-9242-4040)
- Yuzhong Wu (ORCID: https://orcid.org/0000-0001-7372-9239)
- Yue Liu (ORCID: https://orcid.org/0000-0001-9615-0676)
- Du You-Wei (ORCID: https://orcid.org/0009-0004-2022-7234)
- Hao Xia (ORCID: https://orcid.org/0000-0001-6172-2152)
- Zhijing Yang
- Zheng‐Jun Wu
- Meng‐Ning Lan
- Yu Xu
- H Zhang
Institutions
- Fudan University (CN)
- Shanghai Ocean University (CN)
Publication Details
- Journal
- International Journal of Eating Disorders
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1002/eat.24442
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00