Enhancement Of Solubility And Dissolution Rate Of Nimodipine Solid Dispersion Technique By Solvent Evaporation Method And Oro-Dispersible Tablet Formulation

The present study was aimed in developing the solid dispersion studies of combination of the polymers like PEG 6000: PEG 4000 prepared by solvent evaporation technique with ratio of Drug and polymer ratio was 1:1:1 ad formulation of oro dispersible tablet formulations The Nimodipine solid dispersion were evaluated for physicochemical characteristics like drug content and in vitro drug release studies. Form FTIR studies, it concluded that there was no chemical interaction between the drugs and polymers like PEG 6000 and PEG 4000. it can provide promising way to enhance its solubility and dissolution rate. The compatibility of the drug and excipients was confirmed by DSV and XRD analysis which clearly compatibility of the polymer and drug. The optimized formulation NODT-F01 was Compared with the marketed formulation the F1 shows the In vitro drug release at 99.87 % at 140 min. based on the mathematical models, the concluded that formulation F1, the regression value found to be 0.9906 fitted with Higuchi model follows Fickian diffusion and suggests that drug release occurs through diffusion through dispersed vesicles.