Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression‐Related Behaviors by Urolithin B via the SIRT1‐FOXO1 Pathway
This study confirmed that microglial SIRT1 mediates UB's antidepressant effects, positioning UB as a promising therapeutic candidate for depression by targeting neuroinflammatory pathways.
Authors
- Fengai Hu
- Minghu Cui (ORCID: https://orcid.org/0000-0002-5896-8503)
- Jing Du (ORCID: https://orcid.org/0000-0001-6946-4653)
- Fantao Meng (ORCID: https://orcid.org/0000-0003-2539-0589)
- Guoxing Yu
- Chen Li (ORCID: https://orcid.org/0000-0001-5385-6249)
- Wentao Wang (ORCID: https://orcid.org/0000-0001-8952-1088)
- Dan Wang (ORCID: https://orcid.org/0000-0002-8109-789X)
- Wei Li (ORCID: https://orcid.org/0000-0002-6378-7723)
- Yifan Cao
- Lihong Xu (ORCID: https://orcid.org/0000-0002-9334-1271)
- Cuilan Liu (ORCID: https://orcid.org/0000-0003-4879-7445)
- Di Zhao (ORCID: https://orcid.org/0009-0000-4434-5404)
- Jing Liu (ORCID: https://orcid.org/0000-0003-0569-3080)
- Haina Du
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70379
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province