Evaluation of Gadolinium‐Based Contrast Agents in Juvenile Non‐Human Primates Including Behavioral Evaluations Such as Learning and Memory

Gd levels observed in brain tissue of cynomolgus monkey after juvenile exposure to multiples of equivalent clinical doses of all GBCAs tested did not correlate with any adverse morphological or functional findings. This study showed no evidence that exposure to GBCA during development presents a potential risk for long-term effects such as behavioral, neurological, or histopathological findings in the brain, and/or impaired learning or memory.

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Publication Details

Journal
Birth Defects Research
Published
2025-04-01
DOI
https://doi.org/10.1002/bdr2.2470
Citations
3
Primary Topic
Lanthanide and Transition Metal Complexes
Type
article
Field-Weighted Citation Impact
1.55
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article

Evaluation of Gadolinium‐Based Contrast Agents in Juvenile Non‐Human Primates Including Behavioral Evaluations Such as Learning and Memory

Simona Bussi, C. Marc Luetjens, Nathalie Fretellier, Matilde Forni et al.
3 citations
Birth Defects Research
Lanthanide and Transition Metal Complexes
1.55
article

Evaluation of Gadolinium‐Based Contrast Agents in Juvenile Non‐Human Primates Including Behavioral Evaluations Such as Learning and Memory

Simona Bussi, C. Marc Luetjens, Nathalie Fretellier, Matilde Forni, Paul A. Jones, Daniela Smieja, Alessandra Coppo, Christian Günther, Oliver Czupalla, Philippe Bourrinet
article en
3 citations

Abstract

Gd levels observed in brain tissue of cynomolgus monkey after juvenile exposure to multiples of equivalent clinical doses of all GBCAs tested did not correlate with any adverse morphological or functional findings. This study showed no evidence that exposure to GBCA during development presents a potential risk for long-term effects such as behavioral, neurological, or histopathological findings in the brain, and/or impaired learning or memory.

Birth Defects ResearchVol. 117(4)
Guerbet (France) (FR), Bracco (Italy) (IT), Bayer (Germany) (DE)
Openalex Percentile: Top 18%
Lanthanide and Transition Metal Complexes
1.55
DOISourceOpenAlex
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Evaluation of Gadolinium‐Based Contrast Agents in Juvenile Non‐Human Primates Including Behavioral Evaluations Such as Learning and Memory — Simona Bussi, C. Marc Luetjens, et al. · Birth Defects Research (2025) | TGRS Research Map | TGRS