Glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors combination therapy for adults with type 2 diabetes mellitus: a network meta-analysis
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To evaluate the relative benefits and harms of therapy with glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium-glucose co-transporter-2 inhibitors (SGLT2i), and their combination in adults with type 2 diabetes mellitus. Secondary objectives To determine the relative rankings of GLP-1RA, SGLT2i, and their combination, according to their comparative efficacy for the critical outcomes identified in this review through a network meta-analysis.
Authors
- Bizhar Ahmed Tayeb (ORCID: https://orcid.org/0000-0001-5197-564X)
- Juan Víctor Ariel Franco (ORCID: https://orcid.org/0000-0003-0411-899X)
- Brenda Bongaerts (ORCID: https://orcid.org/0000-0003-4695-7185)
- Alaa A. Osman (ORCID: https://orcid.org/0000-0001-8306-6053)
- Isaac Kinyua Njangiru (ORCID: https://orcid.org/0009-0008-6733-0609)
- Maria-Intí Metzendorf (ORCID: https://orcid.org/0000-0002-4154-5782)
- Nazik M. H. Mohammed
Institutions
- University of Szeged (HU)
- Laikipia University (KE)
- Heinrich Heine University Düsseldorf (DE)
- University of Gezira (SD)
Publication Details
- Journal
- Cochrane Database of Systematic Reviews
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1002/14651858.cd015952
- Citations
- 1
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29