Hydroxychloroquine dose-dependently reduces the risk of incident diabetes in primary Sjögren syndrome patients on glucocorticoids: a nationwide population-based cohort study
Our study demonstrated that HCQ exposure significantly reduces the risk of developing diabetes in patients with pSS. While higher doses of glucocorticoids are associated with an increased diabetes risk, concurrent HCQ use mitigates this risk in a dose-dependent manner.
Authors
- Wei‐Sheng Chen (ORCID: https://orcid.org/0000-0001-8672-180X)
- Yu-Sheng Chang
- Hsiang-Yen Lee
- Tzu‐Tung Kuo (ORCID: https://orcid.org/0000-0002-3571-7760)
- Shu‐Chuan Chen (ORCID: https://orcid.org/0000-0002-3787-2959)
- Tzu-Min Lin (ORCID: https://orcid.org/0000-0003-2742-6282)
- Chi‐Ching Chang (ORCID: https://orcid.org/0000-0001-6301-191X)
- Hui‐Ching Hsu (ORCID: https://orcid.org/0000-0002-1093-6019)
- Yi‐Chun Lin (ORCID: https://orcid.org/0000-0001-6770-4246)
- Jin-Hua Chen
- Yu‐Chuan Shen (ORCID: https://orcid.org/0000-0001-8691-920X)
Institutions
- Idaho State University (US)
- Taipei Medical University Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s13075-025-03542-7
- Citations
- 1
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 1.16