Carboxylation of C(sp<sup>2</sup>)–H bonds in quinolone derivatives with CO<sub>2</sub>: facile synthesis of quinolone carboxylic acids
We report a transition-metal-free and redox-neutral method for the direct carboxylation of C(sp 2 )–H bonds in quinolones with CO 2 , synthesizing significant quinolinone-3-carboxylic acids and derivatives, including pharmaceutically scaffolds.
Authors
- Da‐Gang Yu (ORCID: https://orcid.org/0000-0001-5888-1494)
- Jian‐Heng Ye (ORCID: https://orcid.org/0000-0002-4932-0414)
- Lei Song (ORCID: https://orcid.org/0000-0003-2454-1576)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7758-9675)
- Yunyi Xu
- Yang Su (ORCID: https://orcid.org/0000-0001-6323-3256)
- Tianyu Gao (ORCID: https://orcid.org/0000-0001-5330-8373)
- Changfu Li (ORCID: https://orcid.org/0009-0007-9860-8485)
Institutions
- Sichuan University (CN)
Publication Details
- Journal
- Organic Chemistry Frontiers
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5qo00491h
- Citations
- 1
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities