Depletion of <scp>HSP60</scp> in Microglia Leads to Synaptic Dysfunction and Depression‐Like Behaviors Through Enhanced Synaptic Pruning in Male Mice
HSP60 deletion in microglia leads to overactivation of microglia, impaired synaptic function, and depression-like behaviors, highlighting the importance of microglial homeostasis in mood regulation and the potential therapeutic role of microglial modulation.
Authors
- Wenhui Zhu (ORCID: https://orcid.org/0000-0002-6911-7878)
- Weifen Li (ORCID: https://orcid.org/0000-0001-9396-8528)
- Jinlong Chang (ORCID: https://orcid.org/0000-0001-9831-8137)
- Xiuyan Yang (ORCID: https://orcid.org/0009-0003-8186-650X)
- Liusuyan Tian
Institutions
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- Peking University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- Dali University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/cns.70394
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Southern Medical University
- Nanfang Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province