Gestational trophoblastic disease a perplexing challenge: A case series

Gestational trophoblastic disease a perplexing challenge: A case series - Hydatidiform mole (HM) is classified under gestational trophoblastic disease (GTD). Molar pregnancies originate in villous trophoblasts and are characterized by abnormal chorionic villi with trophoblast hyperplasia as a consequence of overexpression of paternal genes. Gestational trophoblastic neoplasia (GTN) is the subtype of GTD which are invasive or metastatic. The disease process possesses a challenge to manage these cases due to its varied presentations and associated complications. This case series of 6 cases in a tertiary care hospital describes different presentations of hydatiform moles such as haemorrhagic shock, thyrotoxicosis; different types of HM like invasive/ complete/ partial moles and how intraoperative/ postoperative management of Hydatiform moles changes with each case. The Preoperative optimization, intraoperative and postoperative management of HM is challenging for Anaesthesiologist. The role of the multidisciplinary approach in the management is crucial. Keywords: Hydatidiform mole, Gestational trophoblastic disease, Beta-hCG, Hyperthyroidism.