Sesquiterpene lactones from <i>Carpesium abrotanoides</i> L. fruits: characterization and bioactivity profiling
<i>Carpesium abrotanoides</i> L. fruit serves as a key anthelmintic remedy in herbal medicine of China. As a continuation of previous research, two undescribed sesquiterpene lactones, carpeabrolactones A and B (<b>1</b> and <b>2</b>), and four known sesquiterpenoids (<b>3</b>-<b>6</b>) were obtained from the dichloromethane extract of fruits. The structures were established through sufficient spectral data examination and ECD calculation. Compound <b>3</b> displayed moderate anti-influenza A (H3N2) activity (IC<sub>50</sub> = 37.04 μM). In addition, acetylcholinesterase (AchE) inhibitory effects of the isolates were also evaluated <i>in vitro</i>, but none of these presented obvious anti-AchE activities.
Authors
- Yu‐Cheng Gu (ORCID: https://orcid.org/0000-0002-6400-6167)
- Ping Tang (ORCID: https://orcid.org/0000-0003-2533-0156)
- Changhong Huo (ORCID: https://orcid.org/0000-0003-4004-3331)
- Song Liu (ORCID: https://orcid.org/0000-0003-0301-9535)
- Xinyu Zhang (ORCID: https://orcid.org/0000-0003-3472-8393)
- Chao Zhang (ORCID: https://orcid.org/0000-0001-6719-7790)
- Jia‐Yi Zhang (ORCID: https://orcid.org/0000-0001-9301-648X)
- Yufang Wang (ORCID: https://orcid.org/0000-0003-1597-3289)
- Françoise Sauriol
Institutions
- Hebei Medical University (CN)
- Queen's University (CA)
- Syngenta (Switzerland) (CH)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1080/14786419.2025.2491830
- Primary Topic
- Sesquiterpenes and Asteraceae Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00