IL-6 Affects Liver Metabolic Abnormalities Caused by Silicon Exposure by Regulating the PKC/YY1 Signaling Pathway
Silicon dioxide exposure can promote the upregulation of FMO3 expression in hepatocytes by activating Kupffer cells to release IL-6 via the PKC/YY1 pathway, ultimately leading to lipid metabolic disorders and dyslipidemia.
Authors
- Yong Dai (ORCID: https://orcid.org/0000-0002-6840-9158)
- Huihui Tao (ORCID: https://orcid.org/0000-0001-6240-4084)
- Xuansheng Ding (ORCID: https://orcid.org/0000-0002-5585-9010)
- Jian Gao (ORCID: https://orcid.org/0000-0001-6723-0490)
- Jingjing Wang (ORCID: https://orcid.org/0000-0002-3620-6671)
- Jialin Wang (ORCID: https://orcid.org/0000-0001-5387-8210)
- Hui Geng (ORCID: https://orcid.org/0000-0002-8170-7344)
- Hui Zhao (ORCID: https://orcid.org/0009-0001-5118-6461)
- Ye Zhu (ORCID: https://orcid.org/0000-0002-3326-7903)
Institutions
- China Pharmaceutical University (CN)
- Anhui University of Science and Technology (CN)
Publication Details
- Journal
- Genes
- Published
- 2025-04-16
- DOI
- https://doi.org/10.3390/genes16040456
- Citations
- 1
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Anhui Provincial Quality Engineering Project