Prevalence and molecular correlates of acquired <i>EGFR</i> resistance mutations in non-small cell lung cancer (NSCLC)
Acquired resistance mutations in <i>EGFR</i>-mutant NSCLC have a low observed frequency among molecularly-profiled tumors, possibly due to infrequent re-testing of resistant tumors. While T790M and C797S mutations are well-described, we also observed a significant number of L718 mutations in osimertinib-treated patients. These data support NGS evaluation of NSCLC that has become resistant to EGFR TKIs.
Authors
- Carlos Carracedo Uribe
- Jennifer R. Ribeiro (ORCID: https://orcid.org/0000-0002-1685-8568)
- Hossein Borghaei (ORCID: https://orcid.org/0000-0002-2577-4454)
- Luis E. Raez (ORCID: https://orcid.org/0000-0003-2669-5771)
- Hirva Mamdani (ORCID: https://orcid.org/0000-0003-3874-8703)
- Daniel Sumarriva
- Ari M. Vanderwalde (ORCID: https://orcid.org/0000-0002-6842-2563)
- Stephen V. Liu (ORCID: https://orcid.org/0000-0002-4852-3914)
- Misako Nagasaka (ORCID: https://orcid.org/0000-0001-5308-615X)
- Jorge J. Nieva (ORCID: https://orcid.org/0000-0003-1605-4719)
- Yasmine Baca (ORCID: https://orcid.org/0000-0003-2130-0611)
- Mark A. Socinski (ORCID: https://orcid.org/0000-0003-2915-9325)
- Antoinette J. Wozniak
- Hina Khan
- Gilberto Lopes (ORCID: https://orcid.org/0000-0002-7115-4942)
Institutions
- University of Southern California (US)
- Fox Chase Cancer Center (US)
- University of Miami (US)
- John Brown University (US)
- Georgetown University (US)
- Wayne State University (US)
- University of California, Irvine (US)
- California Southern University (US)
- Cancer Institute (WIA) (IN)
- Memorial Healthcare System (US)
- West Cancer Center (US)
- UPMC Hillman Cancer Center (US)
- AdventHealth Tampa (US)
- Caris Life Sciences (United States) (US)
- U-M Rogel Cancer Center (US)
- Florida Atlantic University (US)
- Florida Memorial University (US)
Publication Details
- Journal
- Expert Review of Anticancer Therapy
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1080/14737140.2025.2491648
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52