Detecting red blood cell protein antigens by tandem mass spectrometry

MS/MS can successfully detect peptides from several blood group systems but only detected a subset of their common RBC antigens. Further sample enrichment and MS/MS detection improvements will need to occur before MS/MS could be considered a clinical RBC phenotyping modality.

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Publication Details

Journal
Transfusion
Published
2025-04-16
DOI
https://doi.org/10.1111/trf.18252
Primary Topic
Blood groups and transfusion
Type
article
Field-Weighted Citation Impact
0.00

Funders

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article

Detecting red blood cell protein antigens by tandem mass spectrometry

Craig D. Tauscher, Sandip Chavan, Neha Joshi, Jennifer Schieber et al.
Transfusion
Blood groups and transfusion
article

Detecting red blood cell protein antigens by tandem mass spectrometry

Craig D. Tauscher, Sandip Chavan, Neha Joshi, Jennifer Schieber, Akhilesh Pandey, Justin E. Juskewitch, Benjamin J. Madden, Andrew P. Norgan, Ramanath Majumdar, Jane A. Peterson, Eapen K. Jacob
article en

Abstract

MS/MS can successfully detect peptides from several blood group systems but only detected a subset of their common RBC antigens. Further sample enrichment and MS/MS detection improvements will need to occur before MS/MS could be considered a clinical RBC phenotyping modality.

TransfusionVol. 65(5)
Mayo Clinic (US), Manipal Academy of Higher Education (IN)
National Institutes of Health
Good health and well-being
Openalex Percentile: Top 90%
Blood groups and transfusion
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