Mass cytometry analysis reveals a cross-tissue immune landscape in <i>Actinobacillus pleuropneumoniae</i> -induced pneumonia
This study explored the cross-tissue immune dynamic landscape in the APP-induced pneumonia model by utilizing high-dimensional mass cytometry. We discovered that APP-induced immune responses are tissue-specific. Key infection-specific clusters in the spleen and peripheral blood were identified, some of which were previously unrecognized. Meanwhile, the specific functions of APP infection-related immune subsets were explored. The research systematically outlined an overview of immune responses in these tissues, deepening the understanding of APP pathogenesis and laying the foundation for the search for diagnostic and therapeutic targets.
Authors
- Liancheng Lei (ORCID: https://orcid.org/0000-0002-5872-1842)
- Tamim Abdelaal (ORCID: https://orcid.org/0000-0003-2719-5736)
- Fengyang Li (ORCID: https://orcid.org/0000-0001-5102-6284)
- Xuan Jiang (ORCID: https://orcid.org/0000-0003-2749-7304)
- Dexi Chen (ORCID: https://orcid.org/0000-0002-6896-6640)
- Chuntong Bao (ORCID: https://orcid.org/0000-0003-3292-2272)
- Wenjing Wang (ORCID: https://orcid.org/0000-0002-5707-9421)
- Yanyan Tian (ORCID: https://orcid.org/0000-0003-1581-355X)
- Na Li (ORCID: https://orcid.org/0009-0006-9447-6908)
Institutions
- Capital Medical University (CN)
- Jilin University (CN)
- Leiden University Medical Center (NL)
- Beijing YouAn Hospital (CN)
- Delft University of Technology (NL)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1128/spectrum.02665-24
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 0.00