Performance of 2 Finger-Stick Blood Tests to Triage Adults With Symptoms of Pulmonary Tuberculosis: A Prospective Multisite Diagnostic Accuracy Study
Our results show that both Xpert-HR and the MBT are promising non-sputum-based point-of-care tests. The MBT met the World Health Organization target product profile for a triage test, which suggests it should be further developed.
Authors
- Joseph Akol
- Anouk van Hooij (ORCID: https://orcid.org/0000-0003-4134-9674)
- Stephanus T. Malherbe (ORCID: https://orcid.org/0000-0002-7563-8231)
- Annemieke Geluk (ORCID: https://orcid.org/0000-0001-8555-2872)
- Mark Hatherill (ORCID: https://orcid.org/0000-0003-3491-1809)
- Kairaba Kanyi
- Ngoc Le Hong
- Bronwyn Smith
- Paul L. A. M. Corstjens (ORCID: https://orcid.org/0000-0002-0004-0526)
- Henry Ojiambo
- Van Hoang Nguyen (ORCID: https://orcid.org/0000-0002-1571-321X)
- J. Buech
- Mary Nsereko
- Joseph Mendy
- Dang Thi Thanh Thao (ORCID: https://orcid.org/0009-0004-2227-5416)
- Bernadine Fransman
- Balie Carstens
- Van Le
- Tracy Richardson
- Ha Vu Thi Ngoc
- Susanne Tönsing
- Gerhard Walzl (ORCID: https://orcid.org/0000-0003-2487-125X)
- Humphrey Mulenga (ORCID: https://orcid.org/0000-0002-2030-0751)
- Elizma Smit
- Binta Sarr
- Ousainou Cham
- Salieu Barry
- Amie Secka
- Louise Pierneef (ORCID: https://orcid.org/0000-0002-2231-919X)
- Novel N. Chegou (ORCID: https://orcid.org/0000-0002-8690-1699)
- Nguyễn Thụy Thương Thương (ORCID: https://orcid.org/0000-0001-8733-692X)
- Kate Hadley
- Justin Shenje (ORCID: https://orcid.org/0000-0003-3054-3930)
- Isaac L. Johnson (ORCID: https://orcid.org/0000-0002-8869-3010)
- Karen M. Dobos (ORCID: https://orcid.org/0000-0001-7115-8524)
- Awa Gindeh
- Hau Nguyen Thi
- Harriet Mayanja‐Kizza (ORCID: https://orcid.org/0000-0002-9297-6208)
- Stanley Kimbung
- Elma van Rooyen
- Olumuyiwa Owolabi (ORCID: https://orcid.org/0000-0003-4316-5123)
- Emmanuel Moreau (ORCID: https://orcid.org/0000-0002-8004-5019)
- Thomas J. Scriba (ORCID: https://orcid.org/0000-0002-0641-1359)
- Alhaji Jobe
- Son Vo Thanh
- Morten Rühwald (ORCID: https://orcid.org/0000-0002-1597-441X)
- Gerard Tromp (ORCID: https://orcid.org/0000-0002-7761-0806)
- Alicia Chetram
- Momodou W. Jallow (ORCID: https://orcid.org/0000-0001-9748-538X)
- Jayne S. Sutherland (ORCID: https://orcid.org/0000-0002-7083-4997)
- Marika Finn
- Helena Kuivaniemi (ORCID: https://orcid.org/0000-0001-5753-8766)
- Rachel Oelofse
- Simba Mabwe
- Abdou K. Sillah (ORCID: https://orcid.org/0000-0001-8332-2475)
- Andriëtte Hiemstra
- Claudia Schacht
- Le Hong Van (ORCID: https://orcid.org/0000-0003-3151-834X)
- Abi-Janet Riley
- Amadou Barry (ORCID: https://orcid.org/0000-0002-0157-8002)
- Adam Penn‐Nicholson (ORCID: https://orcid.org/0000-0002-1883-0059)
- Nicole Bilek
- Michael Odie
- Bintou Njai
- Kim Stanley
- Harriet Mayanja-Kizza
- Monica Davies
- Kim Stanley (ORCID: https://orcid.org/0000-0002-2030-7275)
- Georgetta K. Daffeh
- Momodou Rashid
- Saidah Menya
- Veronica Kizza
- Yusuf Kironde
- Deborah Banturaki
- Immaculate Nahereza
- Simon Okiror
- Immaculate Kemigisha
- Paul Mutumba
- Lilian Murungi
- Joan Nassuna
- Gladys Mpalanyi
Institutions
- South African Medical Research Council (ZA)
- FIND (CH)
- University of Cape Town (ZA)
- Stellenbosch University (ZA)
- Angkor Hospital for Children (KH)
- Leiden University Medical Center (NL)
- University of Oxford (GB)
- London School of Hygiene & Tropical Medicine (GB)
- South African Tuberculosis Vaccine Initiative (ZA)
- MRC Unit the Gambia (GM)
- Catalysis Foundation for Health (US)
- Oxford University Clinical Research Unit (VN)
- Makerere University (UG)
- Colorado State University (US)
Publication Details
- Journal
- Clinical Infectious Diseases
- Published
- 2025-03-07
- DOI
- https://doi.org/10.1093/cid/ciaf105
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Bill and Melinda Gates Foundation
- London School of Hygiene and Tropical Medicine
- University of Oxford
- Universiteit Leiden
- Universiteit Stellenbosch
- National Institutes of Health
- Medical Research Council
- European and Developing Countries Clinical Trials Partnership