<i>FOXR2</i> activation is not exclusive of CNS neuroblastoma
CNS tumors with FOXR2 overexpression manifest significant histological, molecular, imaging, and clinical diversity. While HGGs and PBs with FOXR2 overexpression demonstrated inferior prognosis, CNS NBs showed favorable outcomes. Integrating histologic and molecular diagnostic approaches is imperative for accurate prognostication and optimal therapeutic decision-making.
Authors
- David A. Wheeler (ORCID: https://orcid.org/0000-0002-9056-6299)
- Alexander O. Vortmeyer (ORCID: https://orcid.org/0000-0001-5437-5092)
- Soniya Pinto (ORCID: https://orcid.org/0000-0001-5552-6163)
- Matthias A. Karajannis (ORCID: https://orcid.org/0000-0002-7151-6528)
- Maria Cardenas (ORCID: https://orcid.org/0000-0002-8183-9785)
- Daphne Li (ORCID: https://orcid.org/0000-0001-9591-6406)
- Emily Hanzlik (ORCID: https://orcid.org/0000-0002-8485-4462)
- Jason Chiang (ORCID: https://orcid.org/0000-0003-3623-8996)
- Patrick R. Blackburn (ORCID: https://orcid.org/0000-0003-0658-1275)
- Christopher L. Tinkle (ORCID: https://orcid.org/0000-0001-5552-2664)
- Giles W Robinson (ORCID: https://orcid.org/0000-0001-7441-9486)
- Qunyu Zhang (ORCID: https://orcid.org/0000-0002-6279-717X)
- Arzu Onar‐Thomas (ORCID: https://orcid.org/0000-0003-1005-2413)
- Sandeep Kumar Dhanda (ORCID: https://orcid.org/0000-0003-1381-7434)
- Mohammad K. Eldomery (ORCID: https://orcid.org/0009-0005-5699-6008)
- Alexa N Siskar
- Xiaoyu Li (ORCID: https://orcid.org/0000-0001-8017-207X)
- Tong Lin (ORCID: https://orcid.org/0000-0001-5390-2487)
- Gerald F. Reis (ORCID: https://orcid.org/0009-0009-9875-1462)
- Ravi Raghavan
Institutions
- Loma Linda University Medical Center (US)
- St. Jude Children's Research Hospital (US)
- Memorial Sloan Kettering Cancer Center (US)
- Loma Linda University (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- Memorial Healthcare System (US)
- Advocate Children's Hospital (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1093/neuonc/noaf076
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- V Foundation for Cancer Research
- Memorial Sloan-Kettering Cancer Center
- American Lebanese Syrian Associated Charities
- National Institutes of Health
- National Cancer Institute