<i>FOXR2</i> activation is not exclusive of CNS neuroblastoma

CNS tumors with FOXR2 overexpression manifest significant histological, molecular, imaging, and clinical diversity. While HGGs and PBs with FOXR2 overexpression demonstrated inferior prognosis, CNS NBs showed favorable outcomes. Integrating histologic and molecular diagnostic approaches is imperative for accurate prognostication and optimal therapeutic decision-making.

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Publication Details

Journal
Neuro-Oncology
Published
2025-04-15
DOI
https://doi.org/10.1093/neuonc/noaf076
Primary Topic
Neuroblastoma Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

FOXR2 activation is not exclusive of CNS neuroblastoma

David A. Wheeler, Alexander O. Vortmeyer, Soniya Pinto, Matthias A. Karajannis et al.
Neuro-Oncology
Neuroblastoma Research and Treatments
article

FOXR2 activation is not exclusive of CNS neuroblastoma

David A. Wheeler, Alexander O. Vortmeyer, Soniya Pinto, Matthias A. Karajannis, Maria Cardenas, Daphne Li, Emily Hanzlik, Jason Chiang, Patrick R. Blackburn, Christopher L. Tinkle, Giles W Robinson, Qunyu Zhang, Arzu Onar‐Thomas, Sandeep Kumar Dhanda, Mohammad K. Eldomery, Alexa N Siskar, Xiaoyu Li, Tong Lin, Gerald F. Reis, Ravi Raghavan
article en

Abstract

CNS tumors with FOXR2 overexpression manifest significant histological, molecular, imaging, and clinical diversity. While HGGs and PBs with FOXR2 overexpression demonstrated inferior prognosis, CNS NBs showed favorable outcomes. Integrating histologic and molecular diagnostic approaches is imperative for accurate prognostication and optimal therapeutic decision-making.

Neuro-OncologyVol. 27(7)
Loma Linda University Medical Center (US), St. Jude Children's Research Hospital (US), Memorial Sloan Kettering Cancer Center (US), Loma Linda University (US), Jackson Memorial Hospital (US), University of Mississippi Medical Center (US), Memorial Healthcare System (US), Advocate Children's Hospital (US)
V Foundation for Cancer Research, Memorial Sloan-Kettering Cancer Center, American Lebanese Syrian Associated Charities, National Institutes of Health, National Cancer Institute
Peace, Justice and strong institutions
Openalex Percentile: Top 87%
Neuroblastoma Research and Treatments
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