Structural and Functional Insight into Intracameral Cefuroxime Ocular Toxic Syndrome (ICOTS) in Eyes with Disrupted Intraocular Barrier
Intracameral cefuroxime ocular toxic syndrome may induce persistent retinal changes despite fluid resolution in eyes with a disrupted intraocular barrier due to prior vitrectomy. Early OCT assessment can help to identify this condition. Further investigation, incorporating UWF-OCTA and ERG for a comprehensive assessment of ICOTS, along with revised informed consent protocols for patients undergoing cataract surgery with this antibiotic prophylaxis, may be indicated when risk factors are identified.
Authors
- Marco Pileri
- Fabian D’Apolito (ORCID: https://orcid.org/0000-0002-7827-4824)
- Massimo Cesareo (ORCID: https://orcid.org/0000-0003-1363-964X)
- Francesco Martelli (ORCID: https://orcid.org/0000-0002-6963-8331)
- Andrea Cusumano (ORCID: https://orcid.org/0000-0001-9302-6063)
- Marco Lombardo (ORCID: https://orcid.org/0000-0002-3874-8327)
- Michele D’Ambrosio (ORCID: https://orcid.org/0000-0002-8651-6256)
- Benedetto Falsini (ORCID: https://orcid.org/0000-0002-1694-1062)
Institutions
- University of Rome Tor Vergata (IT)
- Azienda Ospedaliera San Giovanni Addolorata (IT)
- National Institute of Health (AM)
- New York Genome Center (US)
- University of Macerata (IT)
Publication Details
- Journal
- Ophthalmology and Therapy
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1007/s40123-025-01137-8
- Citations
- 6
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 10.24