Epidemiological and Survival Characteristics of Childhood Lymphomas and Solid Organ Tumors Treated at Our Center

Objective: Childhood cancers constitute 2% of all cancers seen in the world.Overall 5-year survival rate for childhood cancers is 80% in developed, but it is only 30% in underdeveloped countries.In our study have we aimed to analyze the childhood cancer cases treated in our hospital, and to compare the epidemiological characteristics of the patients followed in our center, the distribution of cancer types in our center and the overall survival rates, with the data obtained from our national, and international literature.Method: The records of patients aged 0-19 years with lymphomas and malignant solid tumors, who were followed up and treated between December 25,1987 and January 28, 2021 in our department of pediatric oncology were examined.Hospital files of 1326 patient were reviewed retrospectively, and 1175 patients were included in the study.The data were analyzed in SPSS 25.0 package program.Results: In our study, the male/female ratio was 1.2 among 1175 patients diagnosed with lymphoma and malignant solid organ tumor with a mean age of 7.75 years at the time of diagnosis.Considering the subgroup distribution of childhood cancers other than leukemias; central nervous system tumors (23.6%), lymphomas (19.5%) and neuroblastomas (12%) were found to be the most common malignant diseases.The mean follow-up time of our patients was 62.3155.3months, and the mean event-free follow-up period was 50.2049.681months.Five-and 10-year overall survival, and event-free survival rates were 74% vs. 68.9%,and 50.5%, vs. 39%, respectively. Conclusion:In general, survival rates in childhood cancers in our center are close to the average of our region, our country and European countries, but it was found to be lower in some subgroups of our patients compared to developed countries.