Enhancing Recurrence-Free Survival Prediction in Hepatocellular Carcinoma: A Time-Updated Model Incorporating Tumor Burden and AFP Dynamics
Incorporating postoperative AFP dynamics into RFS prediction after HCC resection enhanced prediction accuracy over time, as TBS's influence decreased. This adaptive, time-varying model provides refined RFS predictions throughout follow-up.
Authors
- Luca Aldrighetti (ORCID: https://orcid.org/0000-0001-7729-2468)
- Ana Gleisner (ORCID: https://orcid.org/0000-0002-5040-4105)
- Thomas J. Hugh (ORCID: https://orcid.org/0000-0001-6690-342X)
- Irinel Popescu (ORCID: https://orcid.org/0000-0002-2897-1170)
- Sara Oliveira (ORCID: https://orcid.org/0000-0003-2322-6531)
- Andrea Ruzzenente
- Vincent Lam (ORCID: https://orcid.org/0000-0001-5566-4769)
- Francesca Ratti (ORCID: https://orcid.org/0000-0002-8108-9064)
- Nazim Bhimani (ORCID: https://orcid.org/0000-0003-3995-4285)
- Jun Kawashima (ORCID: https://orcid.org/0000-0003-1072-0776)
- Federico Aucejo (ORCID: https://orcid.org/0000-0001-7841-229X)
- Minoru Kitago
- Guillaume Martel (ORCID: https://orcid.org/0000-0002-1242-2601)
- Timothy Michael Pawlik (ORCID: https://orcid.org/0000-0002-7994-9870)
- Yuki Imaoka (ORCID: https://orcid.org/0000-0003-0882-5341)
- George A. Poultsides (ORCID: https://orcid.org/0000-0002-7584-0405)
- Miho Akabane (ORCID: https://orcid.org/0000-0002-6705-5730)
- Selamawit Woldesenbet (ORCID: https://orcid.org/0000-0002-5023-3561)
- Itaru Endo
- Hugo P. Marques (ORCID: https://orcid.org/0000-0003-3540-0488)
- Feng Shen (ORCID: https://orcid.org/0000-0001-8119-887X)
- Jorge Balaia
- Abdullah Altaf
- François Cauchy
Institutions
- University of Verona (IT)
- The University of Sydney (AU)
- Cleveland Clinic (US)
- University of Ottawa (CA)
- Second Military Medical University (CN)
- Keio University (JP)
- Hôpital Beaujon (FR)
- The Ohio State University Wexner Medical Center (US)
- Westmead Hospital (AU)
- IRCCS Ospedale San Raffaele (IT)
- Hospital Curry Cabral (PT)
- Eastern Hepatobiliary Surgery Hospital (CN)
- Institutul Clinic Fundeni (RO)
- Yokohama City University (JP)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Annals of Surgical Oncology
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1245/s10434-025-17303-y
- Citations
- 5
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 6.61