Carpaine ameliorates synovial inflammation by promoting p65 degradation and inhibiting the NF-κB signalling pathway
CP acts as a 'physiological brake' on NF-κB activation, thereby mitigating synovial inflammation and cartilage destruction in OA. These findings suggest that targeting synovitis via CP could be a promising therapeutic strategy for OA.
Authors
- Daozhang Cai (ORCID: https://orcid.org/0000-0002-9375-7859)
- Haobin Li (ORCID: https://orcid.org/0000-0001-5537-2395)
- Zihao Yao
- Chenglong Pan (ORCID: https://orcid.org/0000-0002-6376-5022)
- Haiyan Zhang (ORCID: https://orcid.org/0009-0002-6401-7090)
- Zhicheng Zhang (ORCID: https://orcid.org/0000-0001-8043-691X)
- Hongbo Zhang (ORCID: https://orcid.org/0000-0003-3316-9403)
- Chun Zeng (ORCID: https://orcid.org/0000-0002-5682-1452)
- Xiaochun Bai (ORCID: https://orcid.org/0000-0001-9087-1376)
- Chang Zhao
- Ziyang Li (ORCID: https://orcid.org/0009-0000-7603-1223)
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1302/2046-3758.144.bjr-2024-0327.r1
- Citations
- 5
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.68