Extended spectrum beta-lactamase producing Escherichia coli and antimicrobial resistance gene sharing at the interface of human, poultry and environment: results of ESBL tricycle surveillance in Kathmandu, Nepal
Our findings indicate high genetic diversity among ESBL E. coli strains from all three sectors and sharing of identical strains and resistance genes within and between sectors. ST131, the globally dominant ESBL E. coli clade is gaining prevalence in Nepal with bla<sub>CTX-M</sub> being the most common ESBL gene across the phylogroups and all source groups. Antimicrobial stewardship should be promoted in one health approach to combat antimicrobial resistance.
Authors
- Benjamin P. Howden (ORCID: https://orcid.org/0000-0003-0237-1473)
- Louise M. Judd (ORCID: https://orcid.org/0000-0003-3613-4839)
- Tulsi Ram Gompo (ORCID: https://orcid.org/0000-0002-0973-0187)
- Runa Jha (ORCID: https://orcid.org/0000-0002-1591-154X)
- Raghavendra Bhatta (ORCID: https://orcid.org/0000-0001-5074-185X)
- Palpasa Kansakar
- Lisa J. Ioannidis (ORCID: https://orcid.org/0000-0003-1287-7347)
- Nisha Rijal (ORCID: https://orcid.org/0000-0001-7391-9091)
- Jyoti Acharya (ORCID: https://orcid.org/0000-0002-0235-8538)
- Sarah Louise Baines (ORCID: https://orcid.org/0000-0002-0557-0518)
- Sharmila Chapagain
- Barun Kumar Sharma (ORCID: https://orcid.org/0009-0008-9721-2355)
- Priya Jha
- Lilee Shrestha
Institutions
- The University of Melbourne (AU)
- Peter Doherty Institute (AU)
- National Public Health Laboratory (NP)
Publication Details
- Journal
- One Health Outlook
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s42522-025-00145-9
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77