Sex, Neural Networks, and Behavioral Symptoms Among Adolescents With Multisite Pain
In this cross-sectional study of 2052 adolescents, sex-related neurophysiological mechanisms were associated with multisite pain. Brain connectivity partially explained the sleep-pain association in female participants only. On replication and evidence of persistence, these findings suggest that female adolescents with pain may especially benefit from interventions targeting sleep disturbances.
Authors
- Chelsea M. Kaplan (ORCID: https://orcid.org/0000-0001-9324-655X)
- Daniel J. Clauw (ORCID: https://orcid.org/0000-0002-8114-7818)
- Jodi A. Mindell (ORCID: https://orcid.org/0000-0001-7628-815X)
- Steven E. Harte (ORCID: https://orcid.org/0000-0002-2929-8694)
- Hannah Becker (ORCID: https://orcid.org/0000-0001-6944-1208)
- Mike Angstadt (ORCID: https://orcid.org/0000-0003-4870-7649)
- Tristin Smith (ORCID: https://orcid.org/0000-0002-0338-5618)
- Esmeralda Hidalgo‐Lopez (ORCID: https://orcid.org/0000-0001-8521-8970)
- Adriene M. Beltz (ORCID: https://orcid.org/0000-0001-5754-8083)
- Mary M. Heitzeg (ORCID: https://orcid.org/0000-0002-6737-2971)
- Andrew Schrepf (ORCID: https://orcid.org/0000-0003-4291-0320)
Institutions
- Children's Hospital of Philadelphia (US)
- University of Michigan (US)
- Saint Joseph's University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.5364
- Citations
- 5
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 6.94