Sex dimorphism in brain cell death after hypoxia-ischemia in newborn piglets
Clinical data suggest that females might be more resistant to perinatal asphyxia than male newborns. The impact of hypoxia-ischemia in certain brain regions and the association of cell death patterns with sex remain unclear. Hypoxic-ischemic male piglets were more vulnerable than females, showing also increased regional vulnerability in both deep gray and white matter areas. Although necrosis was the primary form of cell death for both sexes, male piglets showed more necrosis, whereas apoptosis and caspase-3 activation were higher in females. Neonatal brain injury and therapeutic responses may be sex-dependent due to differences in cell death patterns and molecular mechanisms.
Authors
- Daniel Alonso‐Alconada (ORCID: https://orcid.org/0000-0002-9874-2947)
- Pierre Gressèns
- Ana Catalán (ORCID: https://orcid.org/0000-0002-0418-7904)
- Marc Chillida (ORCID: https://orcid.org/0000-0002-2204-0439)
- Nicola J. Robertson
Institutions
- Inserm (FR)
- University of the Basque Country (ES)
- Délégation Paris 7 (FR)
- Université Paris Cité (FR)
- BioCruces Health research Institute (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Hospital de Basurto (ES)
- London Women's Clinic (GB)
- NeuroDiderot (FR)
- University College London (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1038/s41390-025-04046-5
- Citations
- 3
- Primary Topic
- Neonatal and fetal brain pathology
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Institute for Health and Care Research
- University College London
- Eusko Jaurlaritza
- Euskal Herriko Unibertsitatea
- Medical Research Council
- Agencia Estatal de Investigación
- Berrikuntza + Ikerketa + Osasuna Eusko Fundazioa