Low Th17 cells in patients with cystic fibrosis and allergic broncho‐pulmonary aspergillosis

In CF, AF airway colonization is associated with increased blood counts of Th17-related subsets. However, CF patients with ABPA exhibit lower numbers of CCR4+/CCR6+/CXCR3+ memory CD4 cells and IL-17-secreting CD4 cells compared to control subjects and CF patients without AF sensitization.

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Publication Details

Journal
Pediatric Allergy and Immunology
Published
2025-04-01
DOI
https://doi.org/10.1111/pai.70090
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
0.00
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article

Low Th17 cells in patients with cystic fibrosis and allergic broncho‐pulmonary aspergillosis

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Antifungal resistance and susceptibility
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Low Th17 cells in patients with cystic fibrosis and allergic broncho‐pulmonary aspergillosis

Simona Fiorentini, Marco Chiarini, Piercarlo Poli, Ramona Pezzotta, Rita Padoan, Daniele Moratto, Manuela Cortesi, Arnaldo Caruso, Raffaele Badolato, Mauro Giacomelli, M Salvi, Irene Bellicini, Silviana Timpano
article en

Abstract

In CF, AF airway colonization is associated with increased blood counts of Th17-related subsets. However, CF patients with ABPA exhibit lower numbers of CCR4+/CCR6+/CXCR3+ memory CD4 cells and IL-17-secreting CD4 cells compared to control subjects and CF patients without AF sensitization.

Pediatric Allergy and ImmunologyVol. 36(4)
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), ERN GUARD-Heart (NL), University of Brescia (IT)
Good health and well-being
Openalex Percentile: Top 89%
Antifungal resistance and susceptibility
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