Sarcopenia and Skeletal Muscle Loss after CAR T-cell Therapy in Diffuse Large B-cell Lymphoma
Skeletal muscle loss after CAR T-cell therapy is common and is associated with fatty acid catabolism. Patients with baseline sarcopenia have poor tolerance and reduced survival. Future studies of dietary and exercise interventions may improve CAR T-cell therapy outcomes.
Authors
- Ranran Wu (ORCID: https://orcid.org/0000-0002-6276-1425)
- Marion Subklewe (ORCID: https://orcid.org/0000-0001-9154-9469)
- Dalia Ercan (ORCID: https://orcid.org/0000-0002-2425-0691)
- Michael David Jain (ORCID: https://orcid.org/0000-0002-7789-1257)
- Aleksandr Lazaryan (ORCID: https://orcid.org/0000-0001-9605-6436)
- Karnav Modi (ORCID: https://orcid.org/0000-0003-3351-8829)
- Farhad Khimani (ORCID: https://orcid.org/0000-0003-4828-4711)
- Frederick Lundry Locke (ORCID: https://orcid.org/0000-0001-9063-6691)
- Robert R. Jenq (ORCID: https://orcid.org/0000-0002-5434-439X)
- Bijal Shah (ORCID: https://orcid.org/0000-0003-4328-6021)
- Nicholas Figura (ORCID: https://orcid.org/0000-0002-6885-3320)
- Neeraj Y. Saini (ORCID: https://orcid.org/0000-0001-7435-0933)
- Aditi Saha (ORCID: https://orcid.org/0000-0003-3421-3971)
- Samir Hanash (ORCID: https://orcid.org/0000-0002-4210-1593)
- Marco L. Davila (ORCID: https://orcid.org/0000-0002-6270-3065)
- Jay Y. Spiegel (ORCID: https://orcid.org/0000-0001-6491-0044)
- Pranit Singh (ORCID: https://orcid.org/0000-0001-6374-5614)
- Kai Rejeski (ORCID: https://orcid.org/0000-0003-3905-0251)
- Jerald Noble (ORCID: https://orcid.org/0000-0003-2571-9428)
- Khushali Jhaveri (ORCID: https://orcid.org/0000-0002-0232-3896)
- Ciara L. Freeman (ORCID: https://orcid.org/0000-0002-0662-6480)
- Taiga Nishihori (ORCID: https://orcid.org/0000-0002-2621-7924)
- Nathan H. Parker (ORCID: https://orcid.org/0000-0002-8947-7942)
- Christina A. Bachmeier (ORCID: https://orcid.org/0000-0002-9832-3670)
- Johannes F. Fahrmann (ORCID: https://orcid.org/0000-0001-5088-0198)
- Fabiana Perna (ORCID: https://orcid.org/0000-0002-3744-8672)
- Jennifer B. Dennison (ORCID: https://orcid.org/0000-0003-3067-0972)
- Asmita Mishra (ORCID: https://orcid.org/0000-0003-3065-4294)
- Julio C. Chávez (ORCID: https://orcid.org/0000-0002-2045-6238)
- Kenneth L. Gage (ORCID: https://orcid.org/0000-0001-9314-3876)
- R. S. Thapa (ORCID: https://orcid.org/0000-0003-1519-2861)
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- City Of Hope National Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Minnesota System (US)
- LMU Klinikum (DE)
- Moffitt Cancer Center (US)
- Sylvester Comprehensive Cancer Center (US)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3782
- Citations
- 7
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 7.32
Funders
- Mark Foundation For Cancer Research
- Florida Academic Cancer Center Alliance
- National Cancer Institute